Abstract

DESIGN AND EVALUATION OF RETINYL RETINOATE MICROSPHERES BASED CREAM FOR ANTI-WRINKLE EFFECT

Jaseena P., Nishad K. M.*, Shahana, Husna N. K., Sirajudheen M.K. and Shijikumar P. S.

ABSTRACT

Wrinkles are lines and creases that appear on the surface of the skin. surface. Prodiction of collagen decreases with age that contribute to skin wrinkling. A novel hybrid retinyl retinoate is highly effective in treatment of wrinkling. Retinyl retinoate microspheres offer greater effectiveness, lasting stability and reduced side effects of retinoic acid and retinol. The cream containing retinyl retinoate microspheres showed significant improvement in facial wrinkles. Microspheres were prepared by ionotropic gelation method using sodium alginate polymer and calcium chloride as cross-linking agent. Different microsphere formulations (M1 -M3) were prepared and evaluated for particle size and entrapment efficiency. Different cream formulation is prepared with optimized microsphere formulation and further evaluated for pH, spreadability, drug content and in- vitro drug release study. Among different formulation F5 was selected, which shows better spreadability, pH and drug release. Therefore, it was concluded that prepared retinyl retinoate microsphere cream is best formulation for anti-wrinkling effect. it provide a prolonged therapeutic effect and reduces frequency of dosing.

Keywords: Wrinkle, Microspheres, Retinyl retinoate, cream, Ionotropic gelation method, optical microscopy, Entrapment efficiency, in-vitro drug release.