Abstract

HEMODYNAMIC EFFECTS OF VECURONIUM WITH FENTANYL DURING INTUBATION

Y. Sreehari Bharadwaj*, K. Maneesha Reddy, M. Mounika and Y. Shailaja*

ABSTRACT

During the intubation, neuromuscular blockers are used for the relaxation of the skeletal muscles, along with a local anesthetic. The anesthetic state is a dynamic combination of hypnosis, amnesia, generalized pain, neuromuscular, neurohumoral blockade. The changes in hemostatic factors such as hypothermia, may also affect the distribution of the anesthetic drugs. Aims & Objectives: - The aim of rapid sequence intubation is to obtain smooth and prompt control of the airway in emergency situations. Objective: - To study the hemodynamic changes in healthy anesthetized and with comorbid anesthetized patients during intubation. To assess and illustrate the vecuronium-fentanyl induced bradycardia effect. Methodology: - A descriptive observational study is carried out to study hemodynamic changes with fentanyl and vecuronium are administered during intubation. Results: - A total of 150 patients were enrolled into study. Systolic blood pressure, Diastolic blood pressure, heart rate was monitored at time period of during administration, after 5 minutes and 3o minutes respectively. Parameters like MAP were calculated based on data collected. Mean averages of heart rate in subjects were decreased as During administration (105.44), after 5 min (97.91), after 30 min (80.2). Mean averages of systolic blood pressure were noticed as 124.1 during administration, within 5 min (112.2), within 30 min (105). Mean averages of diastolic blood pressure were noticed as 77.4, 71.7, 65.8 respectively. Mean averages of mean arterial pressure were also decreased as 92.9, 85, 77.1 respectively. Conclusion: - The study showed that vecuronium has bradycardia effect and this effect is progressed in combination with fentanyl.

Keywords: Hemodynamic effects, Vecuronium, Fentanyl.