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FORMULATION AND IN-VITRO EVALUATION OF NICARDIPINE SUSTAINED RELEASE TABLETS
Dr. Sailesh Kumar Ghatuary, Dr. Satkar Prasad, Kalpna Prajapati and
ABSTRACT Nicardipine is a calcium channel blocker, which has short half-life, makes the development of sustained release (SR) dosage form. The present work was to formulate a sustained release matrix dosage form of Nicardipine by using different concentrations of natural polymers to achieve better bioavailability and also to reduce dosing frequency and side-effects. Nicardipine tablets were prepared by wet granulation method. Formulated tablets were also characterized by various parameters like thickness, weight variation test, drug content uniformity, hardness, friability and the in-vitro release rate profile. FT-IR spectra revealed that there was no interaction between drug and polymers. Tablets were subjected to In-Vitro drug release in 6.8 pH phosphate buffer. From among all the developed formulations, NCD7 formulation sustained the drug release for longer period of time as compared to other formulations. So, NCD7 was selected as the best formulation. The optimized formulation NCD7 which releases the Nicardipine in sustained manner in 1st hour it releases 9.3% but the remaining drug release was sustained up to 12 hours. Keywords: Nicardipine, Sustained release, calcium channel blockers. [Download Article] [Download Certifiate] |