Abstract

A RATIONALITY ASSESSMENT ON DRUG UTILIZATION AND EVALUATION OF PROTON PUMP INHIBITORS (PPIS)

Dr. Mohammed Abuzar Ghufran*, Y. Sreehari Bharadwaj and Wajiha Zehra

ABSTRACT

The study aimed to evaluate the rational use of proton pump inhibitors. A prospective observational study performed on 151 patients at Care hospitals Nampally from October 2016-May 2017 in inpatients ward. The handling of inpatient prescriptions was carried out and assessed to determine the prescribing pattern and drug related problems associated with it. The case sheets of the patients were reviewed for PPIs prescription and relevant data was taken Out of 151 patients Pantoprazole was prescribed in 85% patients, Pantoprazole + Domperidone in 5%patients, Rabeprazole in 4% patients, Rabeprazole + Domperidone in 2% patients, Esomeprazole in 2% patients. Most commonly prescribed ppi in the study was pantoprazole. Moving to dose prescribed, out of 151 patients, 131 were prescribed with optimal dose of ppi and 20 patients were prescribed with higher dose of ppi. The study also identified that out of 151 patients, 13 patients were showing moderate drug –drug interactions and no major interaction was found. The outcomes demonstrate the challenges of PPI use was accompanied by unapproved indications, frequent inappropriate co-prescription with GCs and excessive dosages. Efforts should be paid to promote rational use and guarantee the decision of appropriate PPI therapy in the future.

Keywords: PPI - Proton Pump Inhibitors, Drug-Drug Interactions, Rabeprazole, Pantoprazole and Domperidone.