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CLOZAPINE WITHDRAWAL INDUCED CATATONIA: A CASE SERIES
*Dr. Nishikant M. Throat and Dr. Shaunak Patil
ABSTRACT Catatonia is a symptom of behavioral and motor disturbance and can occur in several disorders including neurodevelopmental, psychotic, bipolar, depressive disorders and other medical conditions. Catatonia occurring due to clozapine-withdrawal has been documented in the medical literature as case reports.[1,9,10] Prolonged use of clozapine leading to increase in GABA activity and resultant GABA receptor adaptations may result in catatonia after abrupt withdrawal of the clozapine. We are discussing here a case series of two patients who presented with catatonia following the withdrawal of clozapine. These two cases of catatonia improved with the treatment with Lorazepam and Electroconvulsive therapy. Keywords: Catatonia, Clozapine, Withdrawal, Schizophrenia. [Download Article] [Download Certifiate] |