Abstract

FORMULATION AND EVALUATION OF TRANSDERMAL PATHES OF ANTI HIV DRUG

Pragati Chandel*, Dr. Nitendra Sahu and Aditya Tiwaril

ABSTRACT

Transdermal patches of Lamivudine drug was formulated developed and characterized. The Lamivudine sample was white color in powder form. The melting point of Lamivudine was observed 176 0C. Lamivudine are found to be freely soluble in dichloromethane, ethanol, acetone, slightly soluble in methanol and acetonitrile, practically insoluble in water. the standard curve for Lamivudine in phosphate buffer pH 7.4. The method obeyed Beer‟s law limit in the concentration range of 2-12 mcg/ml at 270 nm with a regression value of 0.996. The identical peaks are also present in drug loaded HPMC, Ethyl Cellulose, PEG and PVP mixed polymeric Transdermal patches. The physicochemical evaluation like the Thickness, Folding endurance, Percentage moisture absorbed, Percentage moisture lost, Drug content uniformity. In-Vitro permeation studies were performed with Franz cell in Phosphate Buffer Saline pH 7.4. In drug Permeation study the formulation TF5 shows maximum drug permeation 95.24% Lamivudine drug at 12 hrs. The drug permeation data of TF5 was plotted for Zero order, First order, Higuchi model and Korsmeyer-Peppas model to evaluate the permeation pattern of the dosage form. From these plots, kinetic values of the drug permeation were determined. Drug released from the matrix devices by diffusion studied with Higuchi's Model and result suggested that the drug permeation follow Higuchi model. There were no physical changes in flexibility of TF5 and physicochemical evaluation parameter was slightly changed during stability studies.

Keywords: Transdermal Pathes, anti HIV, Lamivudine, permeation, HPMC.