Abstract

REVIEW ON MUCOADHESIVE DRUG DELIVERY SYSTEM

Rajat P. Vishwakarma*, Deepak S. Bhambere, Sanjay J. Kshirsagar, Sapna S. Ahirrao, Atul D. Muthal

ABSTRACT

The development of novel drug delivery methods, such as the mucoadhesive system, can improve pharmacological effects. These systems maintain intimate contact with the absorption tissue and the mucous membrane, allowing the drug to be released at the action site, increasing bioavailability and causing local and systemic effects. Adsorption, diffusion, electronic, fracture, wettability, and mechanical theories are now used to explain mucoadhesion. Wetting, adsorption, and interpenetration of polymer chains are all involved in mucoadhesion with a polymeric drug delivery system. Mucoadhesive dosage formulations help to increase medication plasma concentrations as well as therapeutic action. Several factors influence a dosage form's mucoadhesive ability, including the kind of mucosal tissue and the physicochemical properties of the polymeric formulation. As a result, mucoadhesive systems have become commonplace in many mucosal-covered organelles for the transport of active substances for local or systemic action. The buccal method of medication administration offers various advantages over oral administration, including fast action and greater patient compliance, especially in pediatric and geriatric patients. The current review gives a good summary of theories and mechanisms of mucoadhesion, factors affecting mucoadhesion, properties of mucoadhesive polymers, and evaluating methods.

Keywords: as well as therapeutic action. Several factors influence a dosage form's mucoadhesive ability, including the kind of mucosal tissue and the physicochemical properties of the polymeric formulation. As a result, mucoadhesive systems have become commonplace