Abstract

SOLID DISPERSION- A REVIEW BASED ON SOLUBILITY ENHANCEMENT OF POORLY SOLUBLE DRUGS

Dahekar Priyanka Marotrao* and R. B. Wakade

ABSTRACT

Oral route is a most preferred route for administering a drug, but due to poor solubility many drug have limited use in oral administration. The poor water solubility is one of the major problem and various approaches have been made to increase solubility of such drugs. The solid dispersion technology is best for enhancing solubility and and hence dissolution rate of poorly water soluble drugs using water soluble carrier. The term solid dispersion means the dispersion of one or more active ingredients in a hydrophilic inert carrier matrix at molecular level. This solubilization technology emphasizing basically on drug-polymer two component systems in which drug dispersion and its stabilization is used as the key for formulation development. Therefore the technology has been realized as extremely useful tool in improving the dissolution properties of poorly water-soluble drugs and in recent years, a great knowledge has been accumulated about solid dispersion, but their commercial applications are limited. This review article focuses on Definition, Classification, Advantages, Disadvantages, Methods of preparations, Cariers used, Characterization and Applications of solid dispersion.

Keywords: Solid dispersion, Solubility, BCS classification, Carriers, Solubility enhancement, Dissolution.