Abstract

THE DOMINANCE OF FUNGAL INFECTION AFTER POST COVID RECOVERY: A STUDY

Priyadarshini Deka*, Manashi Garg, Rupjyoti Kalita and Subhajit Chowdhury

ABSTRACT

Both Mucormycosis and Aspergillosis represent the most common angioinvasive fungal infection. They usually affect the immunocompromised individuals and are very rare in apparently healthy individuals. The most concerned risk factors for developing the infections are neutropenia due to cancer treatment, hematopoietic and solid organ transplantation, diabetes mellitus, in particular when presenting with ketoacidosis (DKA) and other forms of acidosis. However, immunocompetent subjects can be affected more when troubled with trauma. It is most likely that both mucormycosis and aspergillosis will continue to increase in incidence because the number of organ transplantations, cancer patients, and diabetic patients is on the rise. Iron as an essential element virtually required by all kind of pathogens for their cell growth and development and its metabolism plays an important role in the clinical manifestation of mucorales and emphasizes mostly in the virulence strategy of organism as well as its entry through interactions with endothelial cells lining blood vessels. However, Neutropenia is classically considered as the most presiding risk factor for immune invasive by aspergillosis in immunocompromised patients. In ascending order of immunocompromised state, these include: allergic bronchopulmonary aspergillosis (ABPA), saprophytic aspergillomas, chronic necrotizing aspergillosis, and invasive aspergillosis (IA). The principal management of both the fungal disorders is based on many intense attempts of laboratory diagnosis of the disease at its early phase as well as timely initiation of an effective antifungal therapy.

Keywords: Mucormycosis, Aspergillosis, Immunocompromised patients, neutropenia, immunoinvasive