Abstract

NASAL IN SITU GEL: A REVIEW

Kalyan Subhashrao Rajegore* and Dr. R. B. Wakade

ABSTRACT

Nasal delivery is an alternative to oral or parenteral route of administration due to certain limitations such as absorption of the drug, drug targeting to particular organs can cause a problem for administration through oral route. The nasal route has also been successfully used for bypassing the blood-brain barrier and afterword delivering drug molecules to the central nervous system. Also, lag time related to oral drug delivery is reduces by this route and offers non invasiveness, self-medication, patient comfort, and patient compliance. Natural, synthetic and/or semi-synthetic polymers with in situ gelling behavior can be used alone, or in combination, for the preparation of such systems; the association with bioadhesive polymers is highly desirable in order to further prolong the residence time at the site of action/absorption. Recently, sustained and controlled drug delivery has become the demand, and research has been undertaken in achieving much better drug product effectiveness, reliability and safety. The in situ polymeric system has gained much attention, to develop a controlled release system. It has been used as a vehicle for local and systemic drug delivery. Nowadays, it has created much interest, because of its characteristics of high vascularization, high permeability, rapid onset of action, low enzymatic degradation, and avoidance of hepatic first pass metabolism, The main aim of this review is to provide knowledge regarding in situ gel for nasal administration.

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