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DETERMINATION AND VALIDATION OF UV METHOD FOR THE ESTIMATION OF ACEBROPHYLLINE IN BULK AND ITS TABLET DOSAGE FORM – A REVIEW
Jansi Rani S.*, Prathap B., Malathi S., Mathivanan M., Ramalingasamy N., Ranjith Kumar E., Sowmiya C.
ABSTRACT A simple, precise, accurate UV method was developed for the determination of Acebrophylline in bulk and tablet dosage form. The λmax of Acebrophylline was found to be 274nm. The method showed high sensitivity with linearity in the range of 2-20μg/ml. The drug was estimated the percentage purity was found to be 99.50%. The coefficient Regression was found to be 0.9994. The Regression of the curve was found to be Y = 0.0185x-0.0027. The percentage R&D value of the interday and intraday analysis of Acebrophylline was found to be 0.1343% and 0.5926% respectively. The detection quantization limit as LOD is 0.140 and LOQ is 0.4262 calculated respectively. The percentage R&D value of the drug found to be 0.515. The low percentage R&D value indicated that the developed method as good precision. The percentage purity of Acebrophylline present in tablet formulation was calculated and found to be 99.50%. The percentage RSD value was found to be 0.7854. The percentage recovery value, that is Average 100.82%, indicated the accuracy, specificity of the method. The results obtained were within the acceptance criteria for the respective parameters. Keywords: . [Download Article] [Download Certifiate] |