Abstract

THE PREVALENCE OF ELEVATED SERUM CREATININE IN HIV INFECTED PATIENTS AT UUTH HIV CLINIC. A TWO YEAR RETROSPECTIVE STUDY

Eyoh J. E.*, Ukpo A. E., Umoffia E. M. and Bassey A. E.

ABSTRACT

Renal disease is a relatively common complication in patients with Human Immunodeficiency Virus (HIV) disease. HIV Nephropathy can result from direct kidney infection with HIV or from the adverse effects of antiretroviral drugs. Previous studies reported that approximately 10% of the patients with HIV infection develop HIV – Associated Nephropathy (HIVAN). However over the last decades, morbidity and mortality as a result of HIV-1 infection has remarkably decreased with the availability of potent new antiretroviral drugs. The aim of the study was to determine the prevalence of HIVAN with elevated creatinine levels in patients living with HIV in the University if Uyo teaching hospital in South- South Nigeria for a period of two years. The methodology employed was collection of samples with vacutainer needles and bottles from the clinic side laboratory and separating the samples immediately after collection into vials bottles for invitro analysis using Selectra Junior chemistry analyser in the retroviral laboratory of the University of Uyo teaching hospital. A total of 1,500 samples from patients for the past two years were reviewed. A total of 271 patients had complicated Nephropathy. This mounting to 18.1% cases of HIVAN in University of Uyo Teaching Hospital, South-South Nigeria. Age and Sex is strongly associated with abnormal creatinine level among the People living with HIV (PLWHIV). Older patient are more likely to have abnormal creatinine. Also male are more likely to have abnormality than female. The significant was P < 0.0001. HIVAN remains an important complication of HIV infection in blacks even in recent years.

Keywords: Prevalence, Human Immunodeficiency Virus – Associated Nephropathy – HIVAN, Creatinine, Urea.