Abstract

SPECTROPHOTOMETRIC QUANTITATIVE ESTIMATION OF ATENOLOL AND LOSARTAN POTASSIUM IN BULK DRUGS AND PHARMACEUTICAL DOSAGE FORM

Sandeep Singh*, Marina Koland

ABSTRACT

A simple, accurate, precise, economical and reproducible UV Spectrophotometric method has been developed for the simultaneous estimation of Atenolol and Losartan Potassium in bulk and in marketed combined tablet dosage form. The stock solutions were prepared in pH 1.2 buffer followed by further required dilutions with pH 1.2 buffer. Vierordt’s simultaneous equation method was developed and is validated statistically as per ICH guidelines. The absorbance maxima of Atenolol and Losartan Potassium were found to be 223.6nm & 205nm respectively. Linearity was observed by linear regression equation method for both drugs in different concentration range. The Correlation coefficient of these drugs was found to be close to 1.00, indicating good linearity. The % R.S.D. were found to be less than 2 % as required by ICH guidelines, which indicates the validity of methods. Statistical analysis proves that the proposed method can be effectively applied for the simultaneous estimation of these two drugs in bulk & combined dosage forms.

Keywords: Atenolol, Losartan Potassium, Vierordt’s simultaneous equation method, etc.