Abstract

SYNTHESIS, CHARACTERIZATION AND ANTIFUNGAL ACTIVITY OF SOME NOVEL GRAMINE BEARING 1,2,4-TRIAZOLES

*Raghu Vardhan Reddy Mekala, Venu Chakravarthula, Ravinder Reddy Kunduru,Srinivas Boche

ABSTRACT

A series of novel 5-(3-dimethylaminomethyl-indol-1-ylmethyl)-4- phenyl-4H-[1,2,4]triazole-3-thiols (5a-f) were synthesized from Nphenyl-[( 3-dimethylaminomethyl-indol-1-yl)acetyl]- hydrazinecarbothioamides (4a-f) through cyclization reaction. The synthesis of the title compounds commenced form commercially available (1H-indol-3-ylmethyl)-dimethyl-amine (gramine) (1) and by involving (3-dimethylaminomethyl-indol-1-yl)-acetic acid ethyl ester (2) and (3-dimethylaminomethyl-indol-1-yl)-acetic acid hydrazide (3) as intermediates. The chemical structures of the all newly synthesized compounds were elucidated by their IR, 1H and 13 C NMR, mass spectral data and elemental analysis. Further, the target compounds were used to find their antifungal activity against various microorganisms.

Keywords: Gramine, 1,2,4-Triazoles, Antifungal activity.