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NOVEL SPECTROPHOTOMETRIC METHODS FOR THE ASSAY OF AN ANTIEPILEPTIC- OXCARBAZEPINE
H. Mallikarjuna, K.S. Lokesh, K.H. Shivaprasad, K.R. Venugopala Reddy*
ABSTRACT New spectrophotometric methods have been developed for the assay of oxcarbazepine (OXP) in pure and pharmaceutical formulations. These methods were based on the formation of chloroform soluble ionassociation complex of OXP with bromocrecol purple in KCl-HCl buffers of pH-2 [Method A] and the diazocoupling of OXP with diazotized p-nitro aniline in basic medium [Method B]. The coloured species exhibited absorption maxima at 412 nm and 510 nm for method A and method B, respectively. The complexes obeyed Beer’s law over the concentration range of 0.4-6 μgml-1 and 0.5-4 μgml-1 with molar absorptivity values of 2.85×104 and 4.24×104 l/ mol/ cm for method A and method B, respectively. Common excipients and additives did not interfere in the assay of OXP by proposed methods. The applicability of the proposed methods was checked by analyzing various dosage forms. The results of analysis were subjected to t-test and F-test. Keywords: oxcarbazepine; spectrophotometry; assay; diazotization; formulations. [Download Article] [Download Certifiate] |