Abstract

AN INSIGHT REVIEW ON IN-SITU GEL DRUG DELIVERY SYSTEM FOR ORAL CANDIDIAISIS

C. Pandian*, A. Abdul Hasan Sathali and G. Abirami

ABSTRACT

Candida albicans causes oral candidiasis, which is one of the most frequent pathogenic disorders affecting the oral mucosa. Though C.albicans is a harmless commensal in the human body, in immunocompromised persons, it becomes an opportunistic pathogen that can cause life-threatening systemic infections in critically ill patients. The key to successful candidal therapy is selecting the right antifungal medication and following the proper drug administration protocol. The cause for inadequate eradication of candidiasis in most cases could be related to antifungal drug's limited residence duration and breakdown in salivary fluid. Because of its characteristics of high vascularization, high permeability, early beginning of action, minimal enzymatic degradation, and avoidance of hepatic first pass metabolism, the in-situ polymeric system has recently received a lot of interest. A novel insitu forming gel applied at the site of action has the potential to overcome the primary practical challenges connected with the treatment of oral candidiasis. The focus of this study is on oral microbiology and the pathophysiology of oral candidiasis, as well as current developments in the in situ gel system for Oral candidiasis.

Keywords: Oral candidiasis, In situ gel, Oral thrush, Candida albicans, Mucoadhesion.