Abstract

LIPID-RELATED MARKERS AND CARDIOVASCULAR DISEASE PREDICTION-PROSPECTIVE STUDY AT TERTIARY CARE HOSPITAL FROM NORTH INDIA

Premshanker Singh*, Manoj Kumar, Brijesh Kumar and P.K. Singh

ABSTRACT

The value of assessing various emerging lipid-related markers for prediction of first cardiovascular events is debated. To determine whether adding information on apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2 to total cholesterol and high-density lipoprotein cholesterol (HDL-C) improves cardiovascular disease (CVD) risk prediction. Individual records were available for 165 544 participants without baseline CVD in 37 prospective cohorts (calendar years of recruitment: 1968-2007) with up to 15 126 incident fatal or nonfatal CVD outcomes (10 132 CHD and 4994 stroke outcomes) during a median follow-up of 10.4 years (interquartile range, 7.6-14 years). Discrimination of CVD outcomes and reclassification of participants across predicted 10-year risk categories of low (

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