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SYNTHESIS AND BIOLOGICAL EVALUATION OF 3, 5- DISUBSTITUTED-1,2,4-OXADIAZOLES AS ANTIHISTAMINIC AGENTS
Sanmati K. Jain* and Jyotsana Nandan
ABSTRACT Ten 3,5-Disubstituted-1,2,4-oxadiazoles were prepared in four steps by using 4-hydroxybenzonitrile as starting material. These compounds were tested for their antihistaminic activity. The compound JN 7 exhibited maximum activity while other compounds were found moderately active in ex vivo studies on field stimulated guinea pig ileum segments induced by (R)-α-methylhistamine. Keywords: Antihistaminic agents, 1,2,4-Oxadiazoles. [Download Article] [Download Certifiate] |