Abstract

ASSOCIATION BETWEEN SMOKING AND SERUM URIC ACID IN INDIAN POPULATION- A STUDY AT TERTIARY CARE HOSPITAL FROM NORTH INDIA

Premshanker Singh*, Ritu Karoli, Nikhil Gupta and D. P. Sigh

ABSTRACT

The aim of this study was to identify any association between serum uric acid and smoking status at a tertiary care hospital from north India. This study used a 561 subjects aged ≥ 20 years. Smoking status was classified into current smokers, never smokers, and ex-smokers. Hyperuricemia was defined as > 7.0 mg/dL for men and > 6.0 mg/dL of serum uric acid for women. Association between smoking and serum uric acid/hyperuricemia was assessed by Pearson's or Spearman's correlation analyses and multivariate logistic regression analysis showing odds ratio (OR) and 95% confidence interval (CI). A significant difference in serum uric acid according to smoking status was identified in female (P < .001) but not in male subjects (P = .069). In female subjects, current smokers and ex-smokers showed higher serum uric acid than never smokers (P < 0.001 of both). Serum uric acid was associated with smoking status in female but not male subjects (r = 0.057, P = .001 and r = 0.025, P = .220, respectively). There was significant difference of smoking status between female subjects with and without hyperuricemia (P < .001). Current smokers had 2.7 times higher likely to have hyperuricemia in female, compared to never smokers (OR 2.674, 95% CI 1.578 – 4.531, P < .001) Study shows that there is strong correlation between smoking and uric Acid.

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