Abstract

THE CORRELATION BETWEEN LIPID PROFILE AND SMOKING-A STUDY AT TERTIARY CARE HOSPITAL FROM NORTH INDIA

Premshanker Singh*, Ritu Karoli and Mridu Singh

ABSTRACT

Smoking is the most preventable cause of most chronic diseases such as cardiovascular disease (CVD). Dyslipidemia is also an important risk factor for CVD. Yet, research has provided contradicting findings regarding the association between smoking and blood lipids. This paper examines the relationship between dyslipidemia and smoking based on the results of a cross-sectional observational study at tertiary care hospital in Lucknow, north IndiaThe objectives were to find out the alterations in serum lipid status among adult male smokers and non-smoker, as well as to evaluate the relationship between the heaviness of smoking and dyslipidemia in smoker subjects. A study was achieved in 320 men with aged 30-63 years which were grouped to smokers and nonsmokers, among them 240 individuals were smokers and the other 80 were nonsmokers. According to the intensity of smoking, the smoker group were divided into three subgroups: mild (A), moderate (B), and heavy (C) smokers. The concentrations of total cholesterol (TC), high density lipoprotein-c (HDL-c), triglycerides (TG), low density lipoprotein-c (LDL-c) and very low density lipoprotein-c (LDL-c) were measured and calculated. The results revealed that concentrations of serum lipid profiles in smokers were significantly higher than that of nonsmokers except in case of high density lipoprotein-c which was significantly reduced among smokers. In addition to that the lipid[6] profile had a significant correlation with the cigarette numbers of that smoked daily; the mean values of all lipid fractions except HDL-c were noticeably increased from group A to group C, while they were decreased in the case of HDL-C. There were significantly different between nonsmokers and different groups of the smoker, the values of TC of groups A, B, and group C were (178.6, 181.7, and 183.5) mg/dl respectively. According to similar arrangement of above smoker groups, the mean values of TG were (238.4, 245.2, and 248.7) mg/dl. In case of HDL- c, they were (31.5, 28.4, and 26.8) mg/dl. Among LDL-c level, they were (194.8, 203.8, and 204.9) mg/dl. In VLDL- c level, they were (47.7, 48.2, and 50.5) mg/dl. The findings of the study showed that smokers (especially heavy smokers) are at much greater risk of increasing dyslipidemia and initiating plaques and various heart diseases than non-smokers.

Keywords: Lipid Profile, Smokers, Dyslipidemia.