Abstract

EVALUATION OF NEURO PHARMACOLOGICAL ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACT OF RUBUS IDAEUS IN EXPERIMENTAL ANIMAL MODELS

MD Faheemuddin, Sana Butool and Musarrath Mubeen*

ABSTRACT

Objective: To evaluate the Neuro pharmacological activity of Ethanolic and Aqueous extracts of Rubus idaeus in Experimental animal models. Methods: The neuro pharmacological activity was determined by several experimental models like, General behavioural, locomotor activity, Anxiolytic activity by Elevated plus maze test, Antidepressant activity by Forced swim test (FST) and Tail suspension test (TST). The extracts dose was determined by acute toxicity studies and determined for activity. The optimum safe concentration was 250 and 500mg/kg body weight for ethanol (EE) and Aqueous (AQE) extracts of RI. Diazepam is used as standard drug. Results: The effective doses in the extracts are EERI and AQRI is 500mg/kg, the ethanolic extract is found to be more effective. The general behaviour, Tail suspension Test and Forced swim Test were performed. It showed a significant (p<0.05) decrease in immobility time in FST. The results were comparable to that of standard drug. Moreover it also showed significant (p<0.05) increase in spontaneous locomotor activity. Conclusion: The presence of Alkaloids, phytosterols and phenolic compounds, the extracts of Rubus idaeus showed better neuro pharmacological activity and this justifies its use in ethanomedicine.

Keywords: Rubus idaeus, Neuro pharmacological, Anxiolytic, Diazepam Antidepressant.