Abstract

A REVIEW ON NANOPARTICLES FOR COLON TARGETTING

Debgopal Ganguly, Soumyadip Ghosh*, Madhumita Banerjee, Pubali Chakraborty and Abid Alam

ABSTRACT

Colon-targeted drug delivery systems have gained a superb deal of attention as potential carriers for the native treatment of colonic diseases with reduced general facet effects and conjointly for the enhanced oral delivery of assorted medical specialty vulnerable to acidic and catalyst degradation in the GIT. Nowadays, the worldwide pharmaceutical marketplace for biologics has grown, and increasing demand for an additional patient-friendly drug administration that shows the significance of colonic drug delivery, a noninvasive delivery approach for macromolecules. Colon-targeted drug delivery systems for macromolecules will offer therapeutic advantages together with better patient compliance (because they are painless and will be self-administered) and lower costs. Therefore, to comprehend additional economical colonic drug delivery for native or general drug effects, various ways square measure explored together with pH-dependent systems, enzyme triggered systems, receptor-mediated systems, and magnetically driven systems. throughout this review, recent advancements in various approaches for planning colon-targeted drug delivery systems and their pharmaceutical applications square measure lined with particular stress on formulation technologies.

Keywords: Colon, Nanoparticles, Targeted drug delivery.