Abstract

GAP JUNCTION PROTEINS, ANGIOGENESIS AND INFLAMMATORY CYTOKINES ARE THERAPEUTIC APPROACH IN SKIN CANCER: REVIEW

Surabhi Bajpai*, Sonu Singhal, Shreshtha Gaur and Rakesh Mishra

ABSTRACT

Skin cancer is the global health hazard, is caused by different signaling pathways. The major cause of the skin carcinogenesis is the ultraviolet radiations. The polyaromatic hydrocarbons are also the cause of skin cancer such as arsenic, 7,12-dimethylbenz[a]anthracene. The intercellular communication occurs through the gap junction proteins plays an important role in skin carcinogenesis as the passage of secondary metabolite occurs through these gap junction proteins. The pathogenesis of the skin carcinogenesis can be assessed using the inflammatory cytokines, angiogenesis markers and gap junction proteins expression. The expression pattern of the aforementioned markers deregulated in the disease condition. Nowadays, the chemoprevention by the dietary products can take place as the chemical drugs or the inhibitors have some side effects. This review, discusses the major correlations between the gap junction proteins, angiogenesis, inflammatory cytokines and skin cancer. Due to the increasing potential of the antioxidant, anti-proliferative, anti-carcinogenic and anti-inflammatory properties of the plant based products; they are used as alternative treatment options.

Keywords: Skin carcinogenesis; Gap junction proteins; Angiogenesis; Inflammatory markers.