Abstract

FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF CARBAMAZEPINE BY USING NATURAL AND SYNTHETIC POLYMERS

Ananthula Swapna*, Chandan kumar brahma, Noel Mann Harshitha, K. Rama

ABSTRACT

A direct compression method was used to prepare fast dissolving tablets containing Carbamazepine as a model drug using natural as well as synthetic superdisintegrants such as chitosanand croscarmellose sodium and sodium starch glycolate respectively. Prepared formulations were evaluated for precompression parameters such as micromeritic properties like angle of repose, %compressibility and Hausner’s ratio etc. Tablets were also subjected to postcompression analysis for the parameters such as weight variation, hardness, friability, in vitro disintegration time, wetting time, drug content, in vitro dissolution study, and stability studies. The prepared tablets were characterized by FTIR for drug-excipient compatibility study. No chemical interaction between drug and excipients was confirmed by FTIR studies. The stability study conducted as per the ICH guidelines and the formulations were found to be stable. The results concluded that amongest all formulations prepared with chitosanshowed better superdisintegrating property than the most widely used synthetic superdisintegrant like croscarmellose sodium and sodium starch glycolate.

Keywords: Fast dissolving tablets, Carbamazepin, chitosan, Croscarmellose sodium, Sodium starch glycolate.