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World Journal of Pharmacy and
Pharmaceutical Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.025

ICV : 84.65

WJPPS Citation

	All	Since 2019
Citation	5450	3969
h-index	23	20
i10-index	134	84

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WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

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WJPPS: NOVEMBER ISSUE PUBLISHED

NOVEMBER 2024 Issue has been successfully launched on 1 NOVEMBER 2024.

Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF RIOCIGUAT

Vaibhav C. Bhor*, Smita S. Aher and R. S. Bacchav

ABSTRACT

Aim: The current paper included the design and evaluation of sustained release matrix tablet of Riociguat using different polymer such as HPMC K4M, HPMC K15M, Ethyl Cellulose, microcrystalline cellulose, Lactose, Starch, magnesium stearate and talc. Materials and Method: laboratory scale six batches was prepared. Tablet form each batch were evaluated with different post evaluation parameter. Micromeritics properties also performed on powdered blend before the tablet compression. Result and Discussion: The result obtained gives information that batch 2 with ratio of HPMC K4M and Ethyl Cellulose as 20:10 retard the drug release to some extent. Drug release followed the non-fickian type of drug release. Conclusion: A systematic study using different batches revealed that by selecting a suitable composition of HPMC K4M polymer and Ethyl Cellulose the desired dissolution profile could be achieved.

Keywords: HPMC K100, Riociguat, sustained release matrix tablet.

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