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FORMULATION DEVELOPMENT AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLET OF RIOCIGUAT
Vaibhav C. Bhor*, Smita S. Aher and R. S. Bacchav
ABSTRACT Aim: The current paper included the design and evaluation of sustained release matrix tablet of Riociguat using different polymer such as HPMC K4M, HPMC K15M, Ethyl Cellulose, microcrystalline cellulose, Lactose, Starch, magnesium stearate and talc. Materials and Method: laboratory scale six batches was prepared. Tablet form each batch were evaluated with different post evaluation parameter. Micromeritics properties also performed on powdered blend before the tablet compression. Result and Discussion: The result obtained gives information that batch 2 with ratio of HPMC K4M and Ethyl Cellulose as 20:10 retard the drug release to some extent. Drug release followed the non-fickian type of drug release. Conclusion: A systematic study using different batches revealed that by selecting a suitable composition of HPMC K4M polymer and Ethyl Cellulose the desired dissolution profile could be achieved. Keywords: HPMC K100, Riociguat, sustained release matrix tablet. [Download Article] [Download Certifiate] |