Abstract

FORMULATION AND EVALUTION OF NIOSOMES

Syed Patcha Hussain*, M.V. Jhansi Priya and Narapusetty Naidu

ABSTRACT

As a model for the niosomal drug delivery system, Acyclovir, an antiviral medication used. Acyclovir niosomes are to be made using two distinct processes in varying ratios of surfactant span 80. In order to increase the drug's bioavailability, acyclovir must be delivered via a new delivery method like niosomes, because its biological half-life is only 2.5 hours, making numerous daily doses necessary. Patients may be more likely to adhere to treatment regimens if niosomal administration is used. To generate stable Acyclovir-loaded Niosomes, the ether injection approach and the hand shaking method can both be used. Before moving on to formulation, a preformulation and drug excipients compatibility research were conducted. Vesicles range in size from 0.25 to 2.5 micrometres in diameter by hand shaking method and 0.25 micrometres to 2.5 micrometres by injection method, respectively. By hand shaking the vesicles, a large percentage of Acyclovir can be encapsulated (75 to 84 percent). Span 80, a non-ionic surfactant, may alter the drug release pattern of all formulations. When compared to the release of Acyclovir from a pure Acyclovir solution, the in vitro release of niosomes was relatively sluggish. According to the results of drug release trials, niosomal preparations were stable at refrigerated temperatures (40 C). It was found that vesicles prepared by hand shaking method were larger than vesicles made using the ether injection approach.

Keywords: Niosomes, Acyclovir, Micrometres, Span 80.