Abstract

FORMULATION DEVELOPMENT OF MODIFIED RELEASE TABLETS OF ANTI DIABETIC DRUG

Shaik Johny Bhasha*, M.V. Jhansipriya and Narapusetty Naidu

ABSTRACT

The work aimed at developing a sustained release formulation of Gliclazide using retardant polymer namely HPMC. IR spectra disclosed that the drug and the polymer are compatible and free from interaction. The granules were found to have good flow property with a range of 23 – 26 degrees. The granules showed very good compressibility index in the range of 13 – 16%. The tablets were found to have uniform weight having weight variation within the allowable limits specified in USP. It varies between 179 mg to 185.5mg. Hardness of the Gliclazide MR tablets were between 4-7 kg/cm2 determined Monsanto hardness tester. All 6 formulations were evaluated for invitro drug release using HPLC up to 16hrs. The drug release pattern was compared with that of marketed formulation. Hence it was the optimized formulation for sustaining the release of Gliclazide. The present works concludes with GMR VI as the best formulation for the sustained release of Gliclazide

Keywords: HPMC, Sustained Release Formulation, Gliclazide.