Abstract

FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF FLOATING TABLETS OF KETOPROFEN

Shaik Muneeruddin*, G. Mary Ratna Anitha and K. Sadhana

ABSTRACT

The aim of present work is to develop a Gastroretentive Floating tablet of Ketoprofen, exerts its analgesic effect by increasing the level of norepinephrine in the brain. It has good absorption window in various regions of GIT, shorter half-life of 2–2.5 hrs, suitable to formulate Gastroprotective Floating tablets. Formulations made by using different ratios of natural polymers like Guargum, Hydroxy propyl methyl cellulose (6 cps & 12 cps). Formulations evaluated for pre-formulation studies like solubility, melting point, determination of λ max, calibration curve and compatability studies were performed. The FTIR analysis assured compatibility of drug and excipients. Tablets were prepared by direct compression technique. After formulation development, the tablets were evaluated for their appearance, hardness, friability, weight variation, disintegration time, content uniformity, buoyancy lag time, total floatation time, In-vitro drug release and stability studies. Based on the evaluation studies F7 formulation was optimized. F7 showed buoyancy lag time (51 sec), total floatation time (˃ 12 hrs), in-vitro drug release 98% for 12hrs. Optimized formulation (F7) subjected for mathematical kinetic model, which reports, correlation coefficient (r2) values for zero-order (0.993), first-order (0.878), higuchi-equation (0.986) and korse-peppas (0.993).

Keywords: Ketoprofen, Gastroretentive Floating tablets, Guargum, HPMC, Buoyancy lag time.