Abstract

FORMULATION AND DEVELOPMENT OF ZIPRASIDONE MOUTH DISSOLVING FILMS USING DoE APPROACH

Megha Agrawal* and Shah Dhiren P.

ABSTRACT

The objective of the current work is to formulate and evaluate the mouth dissolving film of Ziprasidone. It is ideally suitable for the treatment of psychosis. Mouth dissolving dosage forms are gaining popularity in recent times, as these dosage forms requires no water for administration. To develop mouth dissolving films (MDF) of Ziprasidone for the treatment of psychosis, with fast disintegration, optimum morphological properties, and mechanical strength. HPMC E5, PEG- 400 were used as the hydrophilic film-forming polymeric bases. Films were prepared by solvent casting technique. Parameters like in-vitro disintegration time, tensile strength, content uniformity, folding endurance, swelling index, and in-vitro drug release were evaluated. 3² factorial design was used to optimize the amounts of the polymer and the plasticizer. In-vitro dissolution studies showed that 87.97±1.59 of Quetiapine was released within 5 min with an average disintegration time of 35 sec. FTIR spectrophotometry were used to identify drug-excipient interactions.

Keywords: Ziprasidone, Mouth Dissolving Films (MDF), 3² factorial design, In-vitro dissolution studies.