![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
ASSESSMENT OF EFFICACY AND TOLERABILITY OF AZILSARTAN MEDOXOMIL WITH CHLORTHALIDONE IN HYPERTENSIVE PATIENTS WITH AND WITHOUT KIDNEY DISEASE
Dr. Uppara Vishalakshi*, Dr. K. S. Chandana Sai, Dr. Chakali Venkatesh, Dr. Kenchugundu Jagadeesh, Dr. Y. Naveen
ABSTRACT Aim: To determine the efficacy and tolerability of azilsartan medoxomil with chlorthalidone in hypertensive patients with and without kidney disease. Objective: To review the Efficacy and Tolerability of azilsartan medoxomil with chlorthalidone.To determine the dose related decrease in systolic and diastolic blood pressure due to ARB’S and Thiazide diuretics in hypertension with andwithout kidney disease. Materials and methods: A prospective observational study was done in medicine OPD of sri shakti nursing home for six months with fixed dose combination of azilsartan(40mg)plus chlorthalidone(12.5mg) in the age group of 30 to 75 years of moderate hypertensive patients.Change o heart rate was assessed as safety parameter. Results and discussion: The primary eficacy end point was change of mean SBP from baseline to 1 week.Baseline BP was an averaged 165/9mmHg. For the azilsartan/chlorthalidone 40/12.5mg fixed dose combination respectively. The mean standard deviation of SBP and DBP of subjects with and without kidney disease at 12weeks was 13.7 and 6.34 mmHg and 22.5 and 13.2mmHg respectively. Conclusion: Azilsartan medoxomil with chlorthalidone as a dual drug is proved to be more effective in reducing blood pressure in both the group of patients(with and without kidney disease). Azilsartan medoxomil with chlorthalidone was well tolerated in patients with and without kidney disease. Keywords: Azilsartan medoxomil, Blood pressure, Chlorthalidone, Chronic kidney disease, Acute kidney disease. [Download Article] [Download Certifiate] |