Abstract

FORMULATION AND OPTIMISATION OF SELF MICROEMULSIFYING MOUTH DISSOLVING FILM OF ARIPIPRAZOLE

Pepakayala Praveena*, K. Anie Vijetha* and K. Satyendhar Kumar*

ABSTRACT

Aim to formulate and optimization studies of self micro emulsifying mouth dissolving film (SMMDF) of Aripiprazole an atypical Antipsychotic schizophrenic BCS class  drug, a partial D2, 5-HT1A agonist. SMMDF are the oral mucosa drug delivery systems which are formulated by incorporation of Solubility Enhanced drug containing L-SMEDDS targeted for the rapid absorption rate with instant drug release which mainly aimed and focused to treat diseases those need immediate and instant medication within seconds time like Angina pectoris, congestive heart failure, Asthma, Parkinson's convulsions, Antihistamines for allergies etc. On the basis of Aripiprazole solubility study in various excipients, coconut oil and Transcutol and PEG 400 F1 and F2 formulations of SMEDDS are prepared. When compared to the F2 formula, F1 COPT4:1F1(2:8) positive results, globule size- 0.158μm, self-emulsifying time-30.45±0.2s, drug loading efficiency-99.39 % ± 0.17 along with good in-vitro dissolution studies and follows first order kinetics.COPT4:1F1(2:8) SMEDDS formula was incorporated into a standard mouth film formula and prepared F3, F4, F5 SMMDF successfully and evaluated for target onset of time and resultant drug release of the SMMDF F4 formulation was found to be less than 4mins.

Keywords: SMMDF, SMEDDS, solubility, micro-emulsion, self micro-emulsifying mouth dissolving film.