Abstract

TRANSDERMAL DRUG DELIVERY SYSTEM: A REVIEW

Vedant Kumar Gupta*, Nisha Sharma and Ajay Kumar

ABSTRACT

Transdermal delivery builds up one of the most important routes for a new drug delivery system. Since 1981, The Transdermal drug delivery system (TDDS) has been used as a safe and effective drug delivery device. Their potential role in the controlled release is being globally exploited by the scientists with the high rate of enlistment. Today about 74% of drugs are taken orally and are found not to be as efficacious as required. To improve such characters TDDS has emerged. The transdermal drug delivery system is a costly alternative to the conventional formulation. TDDS are dosage forms that involve drug transport to epidermal and or dermal tissues of the skin for local therapeutic effect as long as a very major fraction of drug is transported into the systemic blood circulation. One of the newer technologies to emerge is the delivery-optimized thermodynamic (DOT) patch system, which permits greater drug loading to be achieved a much smaller patch size. Transdermal delivery not only provides controlled, stagnant administration of the drug but also allows continuous Input of drugs with short biological half-lives and repels pulsed entry into the systemic circulation, which mostly causes undesirable side effects. The advantage of the transdermal drug delivery system is that it is a painless technique of administration of drugs.

Keywords: Transdermal drug delivery, Systemic blood circulation, DOT, Painless.