Abstract

TRANSFEROSOMES: MODERN TECHNIQUE FOR EFFECTIVE AND PROMISING TRANSDERMAL DELIVERY OF DRUG

Amit Sharma*, Mehbub Reza, Sunil Yadav

ABSTRACT

Transdermal delivery systems have acquired a lot of interest lately years from their benefits comport to traditional parentral and oral delivery system. The patient comply is boosted because of its self delivered and non invasive property with a regulated release of the therapeutic substance. Skin barrier function outermost layer is the greatest challenge for transdermal delivery system. Ionized chemicals and molecules with molecular weights more than 500 Da do not pass through the skin. As a result, this method can only be used to provide a limited number of medications and one of the potential solutions to this challenge is to encapsulate the medications in transferosomes. They feature a bilayered shape that allows lipophilic and hydrophilic drugs, as well as amphiphilic drugs, to be encapsulated with better penetration efficiencies than conventional liposomes. Because transferosomes are flexible, they may bend and squeeze as an entire vesicle through tiny holes far short than their size. The goal of this paper is to explain the idea of transferosomes, the work of mechanism, various techniques for manufacture and description, variables affects transferosomes features, as well as their latest uses in delivery of transdermal drug.

Keywords: Transdermal drug delivery, Transferosomes, Encapsulation.