Abstract

TRANSFEROSOMES: AN EXPLORATORY REVIEW

Mahbub Reza*, Amit Sharma and Sushil Prasad

ABSTRACT

Novel-controlled drug delivery technologies are gaining greater attention in drug delivery development these days. Recent research has led to the development of important vesicle carriers such as transferosomes as well as ethosomes, which are lipid-based ultra-flexible vesicles. Transferosomes, that can deliver both low and large molecular weight medications transdermally, are recently been implemented. These pharmacological molecules have a broad range of permeability due to their increased solubility and are appropriate for regulated and controlled drug delivery. This causes the penetration of intact vesicles better owing to its high deformability. As they are manufactured from naturally available phospholipids. This may lead to high entrapment efficiency as well as high biodegradability and biocompatibility. It improves the stability of labile compounds while also allowing for controlled release. Transferosomes are distinguished from other vesicles by their synthetic membrane, which is softer, more flexible, and more customizable. Transfersome is valuable for delivering insulin, corticosteroids, protein, and peptides, as well as serving as a carrier for anticancer medications, anesthetics, nonsteroidal anti-inflammatory drugs, and herbal medicines. This paper presents a brief review on transferosomes as vesicular drug delivery system, their advantages, salient features over other vesicle-based transdermal delivery, limitation, composition, mechanism of penetration, method of preparation, additives included in the preparation, and their method of evaluation.

Keywords: Transferosomes, Ultra-flexible, Phospholipids, Transdermal, Corticosteroids.