Abstract

SAFETY EVALUATION OF DR IGUEDO GOKO CLEANSER® POLY-HERBAL FORMULATION IN WISTAR ALBINO RATS

Timipa R. Ogoun, Odangowei I. Ogidi* and Frank-Oputu Ayibaene

ABSTRACT

This study was aimed at evaluating the safety of Dr Iguedo Goko Cleanser® poly-herbal formulation in wistar albino rats. Twenty (20) adult albino rats were used for this research. Dr Iguedo Goko Cleanser® treated groups (n=5) was administered to each rat at 5, 10 and 15 mg/kg body weight. Treatment of the animals was done for 14 days after the 7 days acclimatization before sacrificing them through cervical dislocation. Blood was collected by cardiac puncture, using 5ml syringes and 23G needles into blood sample containers for biochemical evaluation using standard biochemical methods. The results obtained in this study indicate that creatinine and ALT levels were observed to be lower when compared with the control group. Concentrations (10 and 15 mg/kg) of the serum levels of total bilirubin and albumin, ALP (5 and 15mg/kg), AST and total cholesterol (5 and 10mg/kg), total protein (5mg/kg) and urea (5, 10 and 15mg/kg) were observed to be higher when compared with the control. Statistically, there were no significant differences of the evaluated indices at 95% confidence level (P < 0.05). In conclusion, Dr Iguedo Goko Cleanser® poly-herbal formulation can serve as an effective blood cleanser by aiding the kidney in excretion of waste products from the body due to low creatinine levels. The herbal formulation also may not cause hepatocellular damage of the liver due to low ALT levels. However, the study has also revealed nephrotoxic potentials, hepatobiliary dysfunctions and cholestatic alteration effects of the poly-herbal formulation. Therefore, the use of the Dr Iguedo Goko Cleanser® poly-herbal formulation should be under medical supervision and the habitual, higher therapeutic doses and long-term use should be done with utmost caution.

Keywords: Dr Iguedo Goko Cleanser®, Safety, Poly-herbal formulation, Biochemical Parameters, Wistar albino rats.