Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF SUSTAIN RELEASE FLOATING MICROSPHERE OF REPAGLINIDE FOR EFFECTIVE TREATMENT OF DIABETES

Lavlesh Patel*, Anwar Iqbal Khan and Navjot Singh

ABSTRACT

Repaglinide is an oral hypoglycemic agent and first member of meglitinide class, used to treat type-2 diabetes mellitus. The purpose of this research was to prepare a floating drug delivery system of repaglinide. The floating microspheres can be prepared for the improvement of absorption and bioavailability of repaglinide by retaining the system in the stomach for prolonged period of time. Floating microspheres of repaglinide were prepared using different polymers like ethyl cellulose, hydroxy propyl methyl cellulose by solvent diffusion-evaporation method. The microspheres had smooth surfaces with free-flowing and good-packing properties. The yield of the microspheres was up to 72.56±0.65% and ethyl cellulose microspheres entrapped the maximum amount of the drug. Scanning electron microscopy confirmed their hollow structures with sizes in 375.3nm. The prepared microspheres exhibited prolonged drug release and percentage buoyancy was found to 88.23. The formulated batches were evaluated for percentage yield, particle size measurement, flow properties, percent entrapment efficiency, swelling studies. The formulations were subjected to stability studies and In-vitro release and release kinetics data was subjected to different dissolution models. It was concluded that developed floating microspheres of repaglinide offers a suitable and practical approach for prolonged release of drug over an extended period of time and thus oral bioavailability, efficacy and patient compliance is improved.

Keywords: Repaglinide, Solvent diffusion evaporation method, Ethyl cellulose, Hydroxyl propyl methyl cellulose.