Abstract

EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF GMELINA ARBOREA BARKS

Chandrakanta Goyal*, Dr. P. K. Dubey and Anant Kumar Patel

ABSTRACT

Introduction: Depression is one of the major mental disorders characterized with symptoms such as regular negative moods, decreased physical activity, feelings of helplessness, sluggish thought and cognitive function. Gmelina arborea (Verbenaceae) is a medicinal plant commonly fast growing deciduous plant. A number of active compounds including flavonoids, saponins, terpenoids and cardiac glycosides tannins, glycoside, alkaloids, phenols, steroids, protein, carbohydrate have been identified in Gmelina Arborea. To evaluate the antidepressant activity on Gmelina Arborea bark. Methods: The antidepressant activity of ethanolic extract of Gmelina arborea bark was tested by Forced Swim Test (FST) and Tail Suspension Test (TST) in albino mice. Animals were divided into 4 groups, each group contain 6 animals and orally administered with Normal Saline, Standard Drug, Test 1 and Test 2 drug. Duration of immobility was observed for 6 minutes. Results: It has been observed from our study that both the dose showed significant (P

Keywords: Gmelina Arborea, Forced Swimming Test, Tail Suspension Test, Depression, Antidepressant, Imipramine.