Abstract

EVALUATION OF PONGAMIA PINNATA FOR IT’S BRONCHODILATOR ACTIVITY IN ISOLATED GOAT TRACHEAL CHAIN PREPARATION

Amita Tilak*, Sudhir Singh Gangwar and Mudit Kumar

ABSTRACT

The main objective of the work was to evaluate the use of Pongamia pinnata (PP) seeds for safety and efficacy in the treatment of asthma. The bronchodilator activity of the extract by using different concentraton of methanolic extract at 500,1000 and 1500 μg/ml was evaluated in isolated goat tracheal chain preparations by using standard drug histamine. In the present study, histamine produced dose dependent contraction of goat tracheal chain preparation, as number of papers with bronchodilator activity are reported with use of guinea pig ileum, tracheal chain preparation but yet bronchodilator activity was not carried out using tracheal chain hence present study was designed using tracheal chain preparation. The actual dose required to produce bronchodilation was not known so comparison was made by testing various concentration of drug extract of Pongamia Pinnata. The modified physiological salt solution containing methanolic extract of Pongamia pinnata(1.5 mg/ml) significantly inhibited the contractile effect of histamine thus produces significant bronchodilation. It is concluded that 1500 μg/ml of Pongamia pinnata showed potent bronchodilator activity due to bronchodilator activity.

Keywords: Bronchodilator, Pongamia Pinnata, Histamine, Goat tracheal chain.