Abstract

FORMULATION, CHARACTERIZATION AND IN VIVO EVALUATION OF CARBOHYDRATE STABILIZED CERAMIC NANOPARTICLES OF LORNOXICAM

S. C. Mahajan*, D. B. Bhavsar and Dr. A. A. Phatak

ABSTRACT

The present work involves formulation and characterization of carbohydrate coated ceramic nanoparticles of hydrophobic drug lornoxicam to provide sustained release and improved efficacy of drug. Ceramic nanocarriers were synthesized using colloidal precipitation method. The prepared ceramic nanoparticles were characterized for various parameters such as percentage entrapment efficiency (% EE), particle size, surface morphology, zeta potential, powder X-ray diffraction (powder XRD) and differential scanning calorimetry (DSC). The nanoparticles were found nearly spherical in shape with 189.34 nm particle size and about 72.24% of entrapped drug. DSC analysis confirmed the complete entrapment of drug in ceramic nanoparticles and powder XRD results showed little decrease in the crystalline nature of drug when entrapped in ceramic nanocarriers. In vitro drug release study compared the release of lornoxicam from ceramic nanoparticles was compared with lornoxicam solution and marketed formulation. The result confirmed proved the sustained release of lornoxicam from ceramic nanoparticles following Peppas model for release kinetics. The in vivo anti-inflammatory activity of the formulation was studied by using Rat Paw Edema method and was found to be substantially better,when compared with the pure drug. The formulation was also found to be stable for 3 months under accelerated stability conditions.

Keywords: Lornoxicam, ceramic nanoparticles, colloidal precipitation, calcium phosphate, cellobiose, anti-inflammatory activity.