Abstract

SOLUBILITY ENHANCEMENT OF EZETIMIBE BY USING MIXED HYDROTROPY METHOD

Sarita Sahu*, Shikha Agrawal, Sunita Sonartiya and Rajat Pawar

ABSTRACT

Most of the newly invented chemical drug moieties are poorly water soluble drug. According to BCS classification, class II drugs are considered as poorly water soluble. So enhancement of oral absorption and bioavailability of solid dosage forms remains a challenge to formulation scientists due to their solubility criteria. Purpose of research was to provide a fast dissolving oral dosage form of ezetimibe, which can provide quick onset of action by using concept of mixed hydrotropy. Initially solubility of ezetimibe was determined individually in 4 hydrotropic agents namely urea, sodium acetate, sodium benzoate, sodium citrate at concentration of 10, 20, 30 and 40% w/v solutions using purified water as solvent. Highest solubility was obtained in 40% sodium benzoate solution. Then different combinations of 2, 3 and 4 hydrotropic agents in different ratios were used to determine solubility, so that total concentration of hydrotropic agents was always 40%. Highest solubility was obtained in solution of urea+sodium acetate+sodium benzoate+sodium citrate at optimum ratio of 10:5:20:5.

Keywords: Bioavailability, Ezetimibe, Mixed hydrotopy.