WJPPS Citation

Login

Search

News & Updation

  • Updated Version
  • WJPPS introducing updated version of OSTS (online submission and tracking system), which have dedicated control panel for both author and reviewer. Using this control panel author can submit manuscript
  • Call for Paper
    • WJPPS  Invited to submit your valuable manuscripts for Coming Issue.
  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.
  •  
  • New Impact Factor
  • WJPPS Impact Factor has been Increased to 8.025 for Year 2024.

  • ICV
  • WJPPS Rank with Index Copernicus Value 84.65 due to high reputation at International Level

  • Scope Indexed
  • WJPPS is indexed in Scope Database based on the recommendation of the Content Selection Committee (CSC).

  • WJPPS: NOVEMBER ISSUE PUBLISHED
  • NOVEMBER 2024 Issue has been successfully launched on NOVEMBER 2024.

Abstract

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF IVACAFTOR AND LUMACAFTOR IN BULK AND PHARMACEUTICAL DOSAGE FORM

Rupavath Suresh* and Dr. S. Shobha Rani

ABSTRACT

A simple, Accurate, precise method was developed for the simultaneous estimation of the Ivacaftor and Lumacaftor in bulk and Tablet dosage form. Chromatogram was run through Symmetry C18 150 x 4.6 mm, 5. Mobile phase containing Buffer 0.1% Formic acid:Methanol taken in the ratio 50:50 was pumped through column at a flow rate of 1.0 ml/min. Buffer used in this method was Ortho phosphoric acid. Temperature was maintained at 30°C. Optimized wavelength selected was 285 nm. Retention time of Lumacaftor and Ivacaftor were found to be 2.199 min and 2.825. %RSD of Lumacaftor and Ivacaftor were and found to be 1.2% and 1.1% respectively. %Recovery was obtained as 99.96% and 99.86% for Lumacaftor and Ivacaftor respectively. LOD, LOQ values obtained from regression equations of Lumacaftor and Ivacaftor were 0.53, 0.26 and 1.62, 0.78 respectively. Regression equation of Ivacaftor is y = 19840x + 7052.5, and y = 22138x + 8696.5 of Lumacaftor. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.

Keywords: .


[Download Article]     [Download Certifiate]

Call for Paper

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Online Submission

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More

Email & SMS Alert

World Journal of Pharmacy and Pharmaceutical Sciences (WJPPS)
Read More