Abstract

PEPTIC ULCER: ETIOLOGY AND PATHOGENESIS OF ULCER

Chawalke P. Y.*, Wasmate D. and Bawage S. B.

ABSTRACT

A peptic ulcer ulcer in the stomach or duodenum. The two most common types of peptic ulcer are called "stomach ulcers" and "duodenal ulcers". Peptic ulcers are caused by an imbalance between aggressive substances such as hydrochloric acid (HCL), pepsin, bile refluxed, leukotrienes (LTs), reactive oxygen species (ROS) and immune factors, which include the activity of -mucus-bicarbonate. obstruction, prostaglandins (PGs), mucosal blood flow, cell regeneration and migration, non-enzymatic and enzymatic antioxidants and other growth factors. H infection. pylori and the use of nonsteroidal anti- inflammatory drugs (NSAIDs) are the leading causes of peptic ulcer disease. Also, many factors have been implicated in the pathogenesis of gastric ulcer, among which major factors have been implicated in bacterial infections (Helicobacter pylori), certain drugs (NSAIDs), chemicals (Hcl / ethanol), stomach cancer and minor factors. Depression, smoking, spicy food and malnutrition. The idea of treating ulcers is to reduce the amount of acid produced by your stomach, to reduce the amount of acid produced and to protect the injured area from having time to recover. The main purpose of this review article is to summarize the ulceogenic mechanisms of the various mediators involved in Peptic ulcer disease.

Keywords: Peptic ulcer, Types, Etiology and Pathogenesis of ulcers, Disease.