Abstract

A REVIEW ON MESANGIAL PROLIFERATIVE GLOMERULO NEPHRITIS

Dr. D. Naga SatishBabu*, B.Kumaraswamy, Dr.J.N.Suresh Kumar

ABSTRACT

Mesangial proliferative glomerulo nephritis-a relatively uncommon disorder is a type of glomerulo nephritis associated primarily with the mesangium. It is a very rare kidney disorder characterized by swelling and blood in urine due to the inflammation of glomerulus-an internal kidney structure and an increase mesangial cell number accompanied by antibody depots in the mesangial layer of the glomerulus. The factors that triggers the disorder is unknown till date but is considered to be a type of immune response as it is associated with antibody deposits. Symptoms such as edema, anorexia, Hematuria, Proteinuria and high blood pressure can be seen. It is categorized into three types- MPGN Type 1, MPGN Type 2, MPGN Type 3 based on theinflammation pattern seen in the filters. Several health complications include renal failure, congestive heart failure, atherosclerosis, fluid overload etc. different diagnostical methods include blood and urine analysis to reveal blood/protein levels in urine, analysis BUN and serum creatinine and analysis of lipid levels. Renal biopsy can be done for the confirmation of the disorder. The treatment therapy should be aimed to relieve symptoms and to prevent complications and also improving the kidney function. Therapy includes treatment with Immunosuppressive, corticosteroids, renal dialysis, antibiotics, and diuretics, erythropoietin agonists, anti-platelet therapy, plasma exchange and micro Chinese herbal medicine. However diagnosis should be done carefully and drugs have to be chosen based upon their efficacy and condition of the patients as misdiagnosis can lead to arousal of new infections which lead to further complications.

Keywords: Mesangium, Hematuria, Proteinuria, proliferative, Biopsy, MPGN, IGA.