Abstract

PRESENCE OF ORGANIC VOLATILE IMPURITIES IN PHARMACEUTICAL INGREDIENTS

Pawar P.P.*, Bansode G.V., Bawage S.B. and Nandkishor B. Bawage

ABSTRACT

In medicine, Organic volatile pollutants (OVIs) are a residue solvents are used and produced during the synthesis of the drug substances, or aids used in the manufacture of medicine make-up. These residual solvents are almost never needed items, can change the properties of certain combinations or they are dangerous to human health. OVIs (Organic volatile contamination) also affects the Physico-chemical properties of most wood thing. The purpose of this paper was to review and discuss specific issues of current analytical processes involving gas chromatographic (GC) and other remaining operating methods determination of solvents. GC methods are designed for monitoring this type of pollution in general. The most popular strategies of sample introduction to the gas chromatograph include direct injection, vertical or flexible headspace, a strong base for a small section and one small discharge.

Keywords: Gas chromatography, Residual solvents, Organic volatile impurities.