Abstract

DETERMINATION OF DRUGS BY SUPERCRITICAL FLUID CHROMATOGRAPHY-A REVIEW

Kommareddy Nishitha and Baby Nalanda Revu*

ABSTRACT

Supercritical fluid chromatography (SFC) is a type of separation that is a combination of gas chromatography (GC) and liquid chromatography (LC). SFC commonly uses carbon dioxide as the mobile phase, which necessitates pressurization of the entire chromatographic flow path. Supercritical fluid chromatography is sometimes known as "convergence chromatography" because the supercritical phase represents a state where liquid and gas properties converge. Supercritical fluids combine the benefits of both the gaseous and liquid phases. The density, diffusivity, and viscosity of a supercritical fluid are its distinguishing characteristics. This study proposes a simple, rapid, and environmentally friendly chiral analysis approach for antifungals using supercritical fluid chromatography.

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