Abstract

GASTRO-RETENTIVE IN-SITU DRUG DELIVERY SYSTEM: AN SCIENTIFIC VEIW

Nisarga B. K.*, Raji Raju and Mohammad Ali

ABSTRACT

The simplest and most effective way to administer medication by oral route but due to less residential time in GIT, it cannot release the drug by sustained or controlled rate. The in-situ floating system is innovative system in the form of a gastro-retardant system. The in-situ formulation is a liquid solution in nature and gets converted to gel by a different mechanism that floated on the gastric content which results in improved retention time in the stomach. The formed gel matrix releases the drug by the sustained and controlled rate for a longer period of time. It is more beneficial than traditional system such as cost effective and minimum time-consuming method it can increase patient compliance, minimum toxicity and adverse effect, easy to swallow and reduced dose dumping. This review article gives information regarding gastro-retentive property of floating oral in-situ gel.

Keywords: Floating In-situ Gel, Gastric Residence Time, Gastro-retentive drug delivery