Abstract

ANALYTICAL METHOD DEVELOPMENT TECHNIQUES OF TEDIZOLID: A REVIEW

Naresh Panigrahi* and Mehul H. Jain

ABSTRACT

Tedizolid is an oxazolidinone antibiotic with a wide antibacterial action against gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Tedizolid is a pyridine substituted at position 2 by a 2-methyl-2H-tetrazole-5-yl group and at position 5 by a 2-fluoro-4-[(5R)-5-(hydroxymethyl)-2-oxo-1,3-oxazolidin-3-yl] phenyl group. (5R)-3-[3-fluoro-4- [6-(2-methyltetrazole-5-yl) pyridin-3-yl]phenyl]-5-(hydroxymethyl)-1,3-oxazolidine-2-one is the IUPAC name of Tedizolid. It is administered as a phosphate prodrug to treat acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible bacteria such as Staphylococcus aureus (including MRSA and methicillin-susceptible strains), Streptococcus species, and E. faecalis. It serves as an antibacterial, a pharmacological metabolite, and a protein synthesis inhibitor, among other things. It is a carbamate ester, a pyridine, a tetrazole, an organofluorine molecule, an oxazolidinone, and a primary alcohol. In this work, a quick overview of the analytical methodologies developed to estimate this drug is reviewed.

Keywords: Oxazolidinone antibiotic, Tedizolid, Tedizolid Phosphate, Analytical Techniques, Spectroscopy, Chromatography.