Abstract

ANALYTICAL TECHNIQUES FOR THE DRUGS USED IN CELIAC DISEASE: A REVIEW

Sunitha Katta* and Boga Likitha

ABSTRACT

Celiac disease is a genetic, environmental, and immunologic autoimmune condition. Inflammation, villous atrophy, and crypt hyperplasia in the gut are caused by an immunological response to ingested proteins from rye, barley and wheat gluten. Celiac disease, also called “celiac sprue”, is a chronic inflammatory disorder of the small intestine produced by dietary gluten products in susceptible people. It is a multifactorial disease, including genetic and environmental factors. An Environmental trigger is a gluten, while the genetic predisposition has been identified in the central histocompatibility complex region. Celiac disease is not as rare as assumed initially, with a global prevalence of approximately 1%. The reason behind its under-recognition is mostly since nearly half of those affected do not show conventional gastrointestinal symptoms but instead present with nonspecific signs of nutritional insufficiency or have no symptoms at all. Prednisone, Betamethasone, Dapsone, and Cyclosporine are some of the drugs administered in therapy. The present study provided a quick review of the analytical methodologies established for the estimation of these drugs.

Keywords: Celiac disease, Prednisolone, Betamethasone, Dapsone, Cyclosporine, Analytical techniques.