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DESIGN AND EVALUATION OF ORAL SUSTAINED RELEASE MUCOADHESIVE MICROSPHERES OF TRAMADOL HCl
Sundararajan G.*, T. Srinivas, Sowmya Lakshmi Pallela and S. Manohar Babu
ABSTRACT The major aim and objective of project work is to design and characterize the oral control release mucoadhesive microspheres of the Tramadol Hcl, and to reduce the multiple administration, dosing frequency and improve the patient compliance. Design a mucoadhesive microsphere to improve the absorption of drug by delivering or targeting to the site specific by mucoadhesion approach and to improve efficient absorption and enhanced bioavailability of the drug due to a high surface to volume ratio. Sodium CMC, HPMC K4M, HPMC K100M and carbopol 934P are suitable for development of oral sustained release mucoadhesive microspheres for Tramadol HCl. The microspheres displayed spherical and smooth morphological features. The micromeritic properties like angle of repose, Carr’s index, Hausner’s index demonstrated that the microspheres had excellent flow property. The formulation F4 containing sodium alginate with HPMC K4M showed maximum mucoadhesion. Tramadol HCl release from these mucoadhesive microspheres was slow and extended over longer period of time and depends on concentration of coat material. Drug release was fitted to Higuchi kinetic (R2 is maximum). Keywords: Mucoadhesive Microspheres, Tramadol Hcl, Mucoadhesion. [Download Article] [Download Certifiate] |