Abstract

FORMULATION AND EVALUATION OF FAST DISINTEGRATING FILMS CONTAINING CHLORPHENIRAMINE MALEATE

Shripathy D.*, Deekshitha Rai G. P., Riya Ghodasara, Krishnamurthi Gopal Bhat, Mamatha, Manisha B. S. and A. R. Shabaraya

ABSTRACT

The present study was undertaken with an intention to develop fast disintegrating films of Chlorpheniramine maleate as an antihistaminic drug especially designed for paediatric and geriatric use that provides fast onset of action. Fast disintegrating drug delivery system offers a solution for those patients having difficulty in swallowing tablet/capsules. The film placed on the top or the floor of the tongue instantly gets wet by saliva rapidly hydrates, adhere to tongue and rapidly disintegrates. The solvent casting method was used to prepare the films. Films were formulated using the polymers like HPMC E15, PVA, Crospovidone as fast disintegrating agent, Glycerine as a plasticizer, Citric acid as saliva stimulating agent, Raspberry syrup as a flavouring agent and Sucrose as a sweetening agent. The prepared formulations of films were evaluated for film thickness measurement, weight variation, folding endurance, percentage drug content, in-vitro disintegration time, in-vitro dissolution study. All the formulated films were found to disintegrate within 72 sec. All formulations showed good Physico-mechanical properties. Among six formulations F4 with thickness 0.07±17.320 mm, disintegration time 52 sec. folding endurance 350, % drug content 93.75% and %CDR 94.73% at the end of 15min and selected as optimum formulation.

Keywords: Fast disintegrating films; Chlorpheniramine maleate; Crospovidone.